GluteGuard Intro

Introducing GluteGuard!

What is GluteGuard?

GluteGuard is a novel patented product that could help keep you safe from accidental gluten ingestion.

How Does it Work?

GluteGuard is a natural enzyme and it is specifically formulated to break down accidentally ingested gluten to protect from unwanted symptoms and damage.

GluteGuard Ingredients

GluteGuard is an all natural supplement derived from the skin of the papaya fruit.

The Science of GluteGuard

GluteGuard has been extensively studied. Find out more about the clinical trials that have been performed to date

Get GluteGuard

For participating in our focus groups you now have access to GluteGuard before anyone else

Frequency Asked Questions

We have compiled a list of frequent questions and answers about GluteGuard and how to use it

What is GluteGuard?

GluteGuard is an innovative enzyme supplement for individuals concerned about ingested gluten.

GluteGuard is an enterically coated enzyme called caricain derived from the unripe skin of the papaya fruit (Carica Papaya).

Why is the Enteric Coating Important?

The enteric coating makes sure you get the protection where you need it; in the small intestine. The coating prevents your stomach acids from breaking down caricain in the stomach and allows the enzyme to be more effective in the small intestine compared to other enzyme. 

How Gluten Can Affect You

When traces of gluten are found in your food, they can cause extensive damage to your gut and to other organs indirectly by increased inflammation.

Gluten is composed of proteins called Glutenin and Gliadin. When your body tries to digest gluten it can create dangerous smaller proteins called immunogenic peptides. They are named immunogenic because they can trigger inflammation in your body. This inflammation damages your small intestines, to the point that they no longer work properly, as a result your body cant absorb nutrients to be healthy. This means you have a higher chance of getting certain cancers, heart conditions, anemia and neurological problems.

How GluteGuard Works

GluteGuard is an innovative enzyme supplement for individuals concerned about gluten. The way this enzyme works is very unique in that it is coated to protect it from being degraded in your stomach. It allows Gluteguard to work in the small intestine. The enzyme Caricain is the active ingredient in Gluteguard derived from the skin of an unripe fruit of a papaya. It cuts immunogenic proteins like a pair of scissors better and faster than any other known enzyme that has been studied to date. When gluten and immunogenic peptides are broken down into amino acids they can no longer cause damage. The resulting amino acids end up being safely absorbed and used by your body. This allows your gut to heal and function as it should. 

*GluteGuard has been certified gluten free , GluteGuard also contains sulfites. 

GluteGuard is dairy free

GluteGuard Ingredients

The Science Behind GluteGuard

Enzymes have been studied to protect against accidental Gluten ingestion for some time. These special proteins can break down other proteins. In the case of Gluten most enzymes can’t break it down correctly, as a result your body will create immunogenic peptides that could cause harm and your immune system to react. It was seen in lab tests that adding more enzymes could improve the digestion of gluten reducing the immunogenic peptides. However most enzymes did not perform this task well. Caricain, the active ingredient in GluteGuard, was observed to be the most effective enzyme ever studied at specifically breaking down these immunogenic peptides. 

GluteGuard has Been Studied Clinically in Celiac Disease

In a placebo controlled clinical trial of known celiac patients, people were required to eat 1gm of gluten at breakfast, and take a pill prior to the meal. They endured this gluten challenge for 42 days.

The outcome of this clinical trial was impressive as 93% of patients in the treatment group finished the study and had minimal to no detrimental side effects, whereas 67% of the patients in the placebo group withdrew from the study by the 14th day and refused to take more gluten due to the side effects they were experiencing.

Placebo Group
withdrew from study by day 14 67%
GluteGuard Group
finished 42 days with no side effects 93%

Patients reduced inflammatory markers even by challenging themselves with gluten for 42 days as long as they had GluteGuard to protect them from it 

Compared to placebo Gluteguard offered protection to those suffering from Dermatitis Herpetiformis (DH)

GluteGuard Protected over Placebo
Itch 38%
Gluteguard Protected over Placebo
Number of Lesions 71%
Gluteguard Protected over Placebo
Area of Lesions 81%

GluteGuard has been studied in gluten triggered skin conditions

After 7 days the major features associated with the gluten triggered skin condition called Dermatitis Herpetiformis (DH) were more severe and more common with the placebo compared with enzyme therapy. Before 14 days,  six patients on placebo, had to withdraw from the trial because of the effects of the gluten challenge


  1. Cornell H J, Macrae F A, Melny J, Pizzey C, Cook F, Mason S, Bhathal P & Stelmasiak T. (2005) Enzyme therapy for management of coeliac disease. Scand. J. Gastroent. 40: 1304-1312
  2. Cornell HJ, Czyzewska A, Macrae FA, Rydzewska G, Nasierowska-Gutmejer A, Bednarczuk A, Stelmasiak T. The Effect of Enzyme Supplementation on Symptoms and Duodenal Histology in Celiac Patients. International Journal of Celiac Disease 2016;4(2):40-47.
  3. Zebrowska A, Cornell HJ, Macrae FA, Sysa-Jedrzejowska A, Waszczykowska A, Stelmasiak T. (2014) The effect of enzyme therapy on skin symptoms and immune responses in patients with dermatitis herpetiformis. International Journal of Celiac Disease. 2 (2): 58-63.
  4. Hugh J. Cornell and Teodor Stelmasiak. The Significance of Key Amino Acid Sequences in the Digestibility and Toxicity of Gliadin Peptides in Celiac Disease. International Journal of Celiac Disease. 2016; 4(4):113-120. 
  5. AO, Finlay. (2018). Enzyme Therapy that Can Digest the Toxic Motifs of Gluten as an Aid in the Management of Celiac Disease. International Journal of Celiac Disease. 6. 4-6. 10.12691/ijcd-6-1-3.
  6. Aaron Lerner. Is Enzyme Supplementation Effective Strategy to Reduce the Burden of Gluten Free Diet in Celiac Disease?. International Journal of Celiac Disease. 2016; 4(2):38-39

Try GluteGuard Free!

Complete a quick survey  to help us gather market research as we prepare for the US launch of GluteGuard. We are excited about GluteGuard’s new formulation and want to get your feedback. 

Currently GluteGuard is not commercially available in the US.


F.A.Q. about GluteGuard

GluteGuard is an innovative enzyme supplement that helps protect against symptoms caused by accidental gluten ingestion, for anyone with any medically diagnosed gluten sensitivity.

GluteGuard uses the natural power of the caricain enzyme from the unripe skin of the papaya fruit (Carica Papaya). When taken before a gluten-free meal, GluteGuard enzymes are uniquely able to break down the harmful parts of gluten before they cause symptoms.

Take one (1) GluteGuard tablet immediately prior to eating a gluten-free meal, where you are concerned about the risk of hidden traces of gluten being present.

Taking the tablet before eating ensures that the enzymes are released just before your food reaches the small intestine, allowing the enzymes to begin breaking down the small amounts of gluten before they interact with the intestinal lining. In this way, GluteGuard helps to reduce the occurrence of symptoms caused by inadvertent gluten ingestion in many who follow a gluten-free diet for medical reasons.

We don’t recommend that anyone medically advised to follow a gluten free diet intentionally eats gluten-containing foods. Despite being careful, accidental gluten-contamination is still a very common concern for many. GluteGuard helps protects against the symptoms of accidental gluten ingestion. For peace of mind, use GluteGuard to enhance your gluten-free diet.

The recommended maximum daily dose is four (4) tablets in a single day. Only one tablet (whole) is required per meal. Some who are more sensitive could benefit from taking two (2) tablets up to 30 minutes prior to potential gluten contamination. For prolonged meals, we recommend taking another GluteGuard tablet after an hour. 

We recommend anyone allergic to papaya or latex to seek medical advice before trying GluteGuard.

GluteGuard is recommended for adults only. While the active ingredient in GluteGuard is natural and considered safe for consumption, GluteGuard has only been studied in an adult population.

Additionally, because the tablets are unable to be split or crushed, they may be difficult for young children to take whole.

GluteGuard is not recommended to be taken while pregnant or breastfeeding. While the ingredients are natural and considered safe, GluteGuard has not been clinically tested in a pregnant or breastfeeding cohort.

Unfortunately, no. Doing so would significantly reduce GluteGuard’s effectiveness.

The tablets are coated in a special enteric coating, which ensures that GluteGuard’s active ingredient pass through the acidic environment of the stomach, quickly dissolving once the tablet reaches the small intestine. This ensures that the enzymes are released where they are needed to help protect against symptoms caused by consuming gluten accidentally.

No, GluteGuard will not leave a build-up of residue in your body. Every component of each GluteGuard tablet is digested by the body’s normal processes.